Aurotherapy: A Literature Review and its Implications for the Treatment of Hypergranulation Tissue in Wounds

Lisa Yoon, B.A., Jose Lingao, B.A.

Chronic ulcerations account for a large proportion of the total cost of wound care in the United States, yet only a small fraction of the population suffers from these wounds. Therefore, it is imperative to research and develop alternative treatment options that are both efficacious and economical. Aurotherapy, the use of gold compounds in wound care, has been gaining traction in nonhuman trials. Gold is proposed to increase healing rates by inhibiting matrix metalloproteinases and TGF-B and by enhancing angiogenesis and collagen synthesis. Trials involving human applications, however, are limited in the medical literature. This paper reviews the research to date investing gold and its
potential application in wound care.