The Use of Prophylactic Vitamin C for Prevention of Complex Regional Pain Syndrome in the Foot and Ankle: A Review of the Literature

Stephen Kriger, B.A., Shontal Behan B.S., Sara Shirazi, B.A.

Complex regional pain syndrome is a chronic pain disorder, which typically occurs following trauma or surgery. The condition involves the extremities and is
characterized by disabling pain out of proportion, edema, vasomotor instability, and impaired motor function. While research has not been able to agree on a specific
treatment or prevention of the syndrome, prophylactic vitamin C has been described as a promising, effective form of prevention if given directly following traumatic fracture or surgical intervention.